Curated Information
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Home > Curated Information Page > PubMed Id: 12441002
Shepherd M, et al. (2003) Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Biochem J 370, 429-38 12441002
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S133-p - PDE4B (rat)
Modsite: GHSQRREsFLYRSDs SwissProt Entrez-Gene
Orthologous residues
PDE4B (human): S133‑p, PDE4B iso2 (human): , PDE4B iso3 (human): S118‑p, PDE4B (mouse): S118‑p, PDE4B (rat): S133‑p, PDE4B iso1 (rat): S118‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (rat) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin, IBMX increase
H-89 colforsin, IBMX inhibit treatment-induced increase
cAMP_analog increase
cAMP_analog, H-89 inhibit treatment-induced increase
colforsin increase
H-89 colforsin inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced