Curated Information
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Home > Curated Information Page > PubMed Id: 12640114
Piedra J, et al. (2003) p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol 23, 2287-97 12640114
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y537-p - Yes (human)
Modsite: FtAtEPQyQPGENL_ SwissProt Entrez-Gene
Orthologous residues
Yes (human): Y537‑p, Yes (mouse): Y535‑p, Yes (rat): Y535‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Comments:  Yes activates Fer and Fyn kinases.

Y86-p - CTNNB1 (mouse)
Modsite: VADIDGQyAMTRAQR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y86‑p, CTNNB1 (mouse): Y86‑p, CTNNB1 (rat): Y86‑p, CTNNB1 (rabbit): Y86‑p

Y142-p - CTNNB1 (mouse)
Modsite: AVVNLINyQDDAELA SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y142‑p, CTNNB1 (mouse): Y142‑p, CTNNB1 (rat): Y142‑p, CTNNB1 (rabbit): Y142‑p
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  IEC-18 (epithelial), RWP1 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  human, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (mouse)
KINASE Fer (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Fer (human) transfection of wild-type enzyme
KINASE Fyn (human) transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
genistein decrease
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell adhesion, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (mouse) Disrupts molecular association, regulation cell adhesion, altered co-immunoprecipitation
CTNNA1 (mouse) Disrupts cell adhesion, altered electrophoretic visualization, co-immunoprecipitation, in vitro

Y654-p - CTNNB1 (mouse)
Modsite: RNEGVATyAAAVLFR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p, CTNNB1 (rabbit): Y654‑p