Curated Information
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Home > Curated Information Page > PubMed Id: 21777522
Ren K, et al. (2011) CK2 phosphorylates AP-2α and increases its transcriptional activity. BMB Rep 44, 490-5 21777522
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S429-p - AP-2 alpha (human)
Modsite: TDNNAKssDKEEKHR SwissProt Entrez-Gene
Orthologous residues
AP‑2 alpha (human): S429‑p, AP‑2 alpha iso2 (human): S423‑p, AP‑2 alpha (mouse): S429‑p
Methods used to characterize site in vivo immunoprecipitation, microscopy-colocalization with upstream kinase
Relevant cell lines - cell types - tissues:  293FT
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation, microscopy-colocalization
Comments:  CK2B participates in complex
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  transcription, induced
Comments:  induces AP-2 alpha transcription