Curated Information
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Home > Curated Information Page > PubMed Id: 21734191
Sung TS, et al. (2011) Molecular determinants of PKA-dependent inhibition of TRPC5 channel. Am J Physiol Cell Physiol 301, C823-32 21734191
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S794-p - TRPC5 (human)
Modsite: SGGARAKsKsVSFNL SwissProt Entrez-Gene
Orthologous residues
TRPC5 (human): S794‑p, TRPC5 (mouse): S795‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NKH_477 increase
cAMP_analog increase
H-89 NKH_477 inhibit treatment-induced increase
H-89 cAMP_analog inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  activity, inhibited, intracellular localization
Effect of modification (process):  signaling pathway regulation

S796-p - TRPC5 (human)
Modsite: GARAKsKsVSFNLGC SwissProt Entrez-Gene
Orthologous residues
TRPC5 (human): S796‑p, TRPC5 (mouse): S797‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NKH_477 increase
cAMP_analog increase
H-89 NKH_477 inhibit treatment-induced increase
H-89 cAMP_analog inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  activity, inhibited, intracellular localization
Effect of modification (process):  signaling pathway regulation