Sung TS, et al. (2011) Molecular determinants of PKA-dependent inhibition of TRPC5 channel. Am J Physiol Cell Physiol 301, C823-32 21734191

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S794-p - TRPC5 (human) ▲

Modsite: SGGARAKsKsVSFNL SwissProt Entrez-Gene Orthologous residues TRPC5 (human): S794‑p, TRPC5 (mouse): S795‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes NKH_477 increase cAMP_analog increase H-89 NKH_477 inhibit treatment-induced increase H-89 cAMP_analog inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  activity, inhibited, intracellular localization Effect of modification (process):  signaling pathway regulation

S796-p - TRPC5 (human) ▲

Modsite: GARAKsKsVSFNLGC SwissProt Entrez-Gene Orthologous residues TRPC5 (human): S796‑p, TRPC5 (mouse): S797‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes NKH_477 increase cAMP_analog increase H-89 NKH_477 inhibit treatment-induced increase H-89 cAMP_analog inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  activity, inhibited, intracellular localization Effect of modification (process):  signaling pathway regulation