Curated Information
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Home > Curated Information Page > PubMed Id: 21768120
O'Leary H, et al. (2011) Nucleotides and Phosphorylation Bi-directionally Modulate Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Binding to the N-Methyl-D-aspartate (NMDA) Receptor Subunit GluN2B. J Biol Chem 286, 31272-81 21768120
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T286-p - CAMK2A (human)
Modsite: SCMHRQEtVDCLKKF SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T286‑p, CAMK2A iso2 (human): T286‑p, CAMK2A (mouse): T286‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T286‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NMDAR2B (human) Induces in vitro

T305-p - CAMK2A (human)
Modsite: kLkGAILttMLAtRN SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T305‑p, CAMK2A iso2 (human): T305‑p, CAMK2A (mouse): T305‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T305‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NMDAR2B (human) Disrupts in vitro
Comments:  T305/306 autophosphorylation

T306-p - CAMK2A (human)
Modsite: LkGAILttMLAtRNF SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T306‑p, CAMK2A iso2 (human): T306‑p, CAMK2A (mouse): T306‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T306‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NMDAR2B (human) Disrupts in vitro
Comments:  T305/306 autophosphorylation

S1303-p - NMDAR2B (human)
Modsite: NKLRRQHsyDtFVDL SwissProt Entrez-Gene
Orthologous residues
NMDAR2B (human): S1303‑p, NMDAR2B (mouse): S1303‑p, NMDAR2B (rat): S1303‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CAMK2A (human) Disrupts in vitro