Curated Information
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Home > Curated Information Page > PubMed Id: 21115498
Lin HH, Lai SC, Chau LY (2011) Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1. J Biol Chem 286, 3829-38 21115498
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S473-p - Akt1 (rat)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  H9c2 (myoblast), myocyte-heart
Cellular systems studied:  cell lines, primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HMOX1 (rat) increase
CORM-2 increase

T180-p - P38A (rat)
Modsite: RHTDDEMtGyVATRW SwissProt Entrez-Gene
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  H9c2 (myoblast), myocyte-heart
Cellular systems studied:  cell lines, primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HMOX1 (rat) increase
CORM-2 increase

Y182-p - P38A (rat)
Modsite: TDDEMtGyVATRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  H9c2 (myoblast), myocyte-heart
Cellular systems studied:  cell lines, primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HMOX1 (rat) increase
CORM-2 increase

T454-p - SP1 (rat)
Modsite: SGPIIIRtPTVGPNG SwissProt Entrez-Gene
Orthologous residues
SP1 (human): T453‑p, SP1 (mouse): T455‑p, SP1 (rat): T454‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  H9c2 (myoblast), myocyte-heart
Cellular systems studied:  cell lines, primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CORM-2 increase
LY294002 CORM-2 inhibit treatment-induced increase slight inhibition
SB203580 CORM-2 inhibit treatment-induced increase

T740-p - SP1 (rat)
Modsite: SEGSGTAtPSALITT SwissProt Entrez-Gene
Orthologous residues
SP1 (human): T739‑p, SP1 (mouse): T738‑p, SP1 (rat): T740‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  H9c2 (myoblast), myocyte-heart
Cellular systems studied:  cell lines, primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CORM-2 increase
LY294002 CORM-2 inhibit treatment-induced increase slight inhibition
SB203580 CORM-2 inhibit treatment-induced increase