Curated Information
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Home > Curated Information Page > PubMed Id: 12742231
Goss VL, et al. (2003) SAPK/JNK regulates cdc2/cyclin B kinase through phosphorylation and inhibition of cdc25c. Cell Signal 15, 709-18 12742231
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S168-p - CDC25C (human)
Modsite: SEMKyLGsPIttVPK SwissProt Entrez-Gene
Orthologous residues
CDC25C (human): S168‑p, CDC25C iso3 (human): S125‑p, CDC25C (mouse): S192‑p, CDC25C (frog): S205‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial) [CDC25C (human)], 293 (epithelial) [JNK2 (human)], HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK2 (human)

Y15-p - CDK1 (human)
Modsite: EkIGEGtyGVVykGR SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human