Powis M, Celius T, Matthews J (2011) Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression. Biochem Biophys Res Commun 410, 859-65 21703235

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Y322-p - AHR (human) ▲

Modsite: LCTRGSGyQFIHAAD SwissProt Entrez-Gene Orthologous residues AHR (human): Y322‑p, AHR (mouse): Y316‑p, AHR (rat): Y320‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  MCF-7 (breast cell) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  activity, induced Effect of modification (process):  transcription, induced Comments:  Induce AHR activation