Curated Information
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Home > Curated Information Page > PubMed Id: 21715626
Xiao L, et al. (2011) The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death. J Neurosci 31, 9611-9619 21715626
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y433-p - MST1 (human)
Modsite: kIPQDGDyEFLksWt SwissProt Entrez-Gene
Orthologous residues
MST1 (human): Y433‑p, MST1 iso2 (human): Y433‑p, MST1 (mouse): Y433‑p, MST1 (rat): Y433‑p
Characterization
Methods used to characterize site in vivo immunoassay, immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  'brain, hippocampus, dentate gyrus', HEK293T (epithelial), HT-22 (neuron), Neuro-2a (neuron), SH-SY5Y (neural crest)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  human, mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Abl (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) modification site within consensus motif, phospho-antibody, activation of upstream enzyme, pharmacological inhibitor of upstream enzyme, siRNA inhibition of enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
siRNA H2O2 inhibit treatment-induced increase siRNA for c-Abl decreases phosphorylation
imatinib H2O2 inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, molecular association, regulation, protein stabilization
Effect of modification (process):  apoptosis, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FOXO3A (human) Induces transcription, induced co-immunoprecipitation