Curated Information
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Home > Curated Information Page > PubMed Id: 12522270
Salomon AR, et al. (2003) Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A 100, 443-8 12522270
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y333-p - Abi-1 (human)
Modsite: sstssGGyRRtPsVT SwissProt Entrez-Gene
Orthologous residues
Abi‑1 (human): Y333‑p, Abi‑1 iso2 (human): Y300‑p, Abi‑1 iso3 (human): Y306‑p, Abi‑1 iso11 (human): , Abi‑1 iso12 (human): Y350‑p, Abi‑1 (mouse): Y306‑p, Abi‑1 iso4 (mouse): Y300‑p, Abi‑1 (rat): Y301‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y185-p - Abl (human)
Modsite: TAsDGKLyVsSESRF SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y185‑p, Abl iso2 (human): Y204‑p, Abl (mouse): Y185‑p, Abl iso4 (mouse): Y204‑p, Abl (rat): Y185‑p, Abl iso2 (rat): Y204‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection], K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human, mouse

Y253-p - Abl (human)
Modsite: HKLGGGQyGEVyEGV SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y253‑p, Abl iso2 (human): Y272‑p, Abl (mouse): Y253‑p, Abl iso4 (mouse): Y272‑p, Abl (rat): Y253‑p, Abl iso2 (rat): Y272‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y257-p - Abl (human)
Modsite: GGQyGEVyEGVWKKy SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y257‑p, Abl iso2 (human): Y276‑p, Abl (mouse): Y257‑p, Abl iso4 (mouse): Y276‑p, Abl (rat): Y257‑p, Abl iso2 (rat): Y276‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y393-p - Abl (human)
Modsite: RLMtGDtytAHAGAk SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso4 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection], K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human, mouse

T394-p - Abl (human)
Modsite: LMtGDtytAHAGAkF SwissProt Entrez-Gene
Orthologous residues
Abl (human): T394‑p, Abl iso2 (human): T413‑p, Abl (mouse): T394‑p, Abl iso4 (mouse): T413‑p, Abl (rat): T394‑p, Abl iso2 (rat): T413‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection], K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human, mouse

Y827-p - Ack (human)
Modsite: SFASDPkyAtPQVIQ SwissProt Entrez-Gene
Orthologous residues
Ack (human): Y827‑p, Ack iso3 (human): Y905‑p, Ack (mouse): Y842‑p, Ack iso2 (mouse): Y827‑p, Ack (rat): Y827‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y859-p - Ack (human)
Modsite: KKVsstHyyLLPERP SwissProt Entrez-Gene
Orthologous residues
Ack (human): Y859‑p, Ack iso3 (human): Y937‑p, Ack (mouse): Y874‑p, Ack iso2 (mouse): Y859‑p, Ack (rat): Y859‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y860-p - Ack (human)
Modsite: KVsstHyyLLPERPs SwissProt Entrez-Gene
Orthologous residues
Ack (human): Y860‑p, Ack iso3 (human): Y938‑p, Ack (mouse): Y875‑p, Ack iso2 (mouse): Y860‑p, Ack (rat): Y860‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y177-p - Bcr (human)
Modsite: ADAEKPFyVNVEFHH SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y177‑p, Bcr iso2 (human): Y177‑p, Bcr (mouse): Y178‑p, Bcr (rat): Y178‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

T310-p - Bcr (human)
Modsite: sEQEKRLtWPRRSYs SwissProt Entrez-Gene
Orthologous residues
Bcr (human): T310‑p, Bcr iso2 (human): T310‑p, Bcr (mouse): T312‑p, Bcr (rat): T312‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

S459-p - Bcr (human)
Modsite: GLPyIDDsPsssPHL SwissProt Entrez-Gene
Orthologous residues
Bcr (human): S459‑p, Bcr iso2 (human): S459‑p, Bcr (mouse): S461‑p, Bcr (rat): S461‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection], K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S463-p - Bcr (human)
Modsite: IDDsPsssPHLssKG SwissProt Entrez-Gene
Orthologous residues
Bcr (human): S463‑p, Bcr iso2 (human): S463‑p, Bcr (mouse): S465‑p, Bcr (rat): S465‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection], K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human, mouse

Y591-p - Bcr (human)
Modsite: LAsQLGVyRAFVDNy SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y591‑p, Bcr iso2 (human): Y591‑p, Bcr (mouse): Y590‑p, Bcr (rat): Y590‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y644-p - Bcr (human)
Modsite: NsLEtLLykPVDRVt SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y644‑p, Bcr iso2 (human): Y644‑p, Bcr (mouse): Y643‑p, Bcr (rat): Y643‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y166-p - Cas-L (human)
Modsite: RtGHGyVyEyPSRyQ SwissProt Entrez-Gene
Orthologous residues
Cas‑L (human): Y166‑p, Cas‑L iso3 (human): Y166‑p, Cas‑L (mouse): Y165‑p, Cas‑L (rat): Y165‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S669-p - CBL (human)
Modsite: PKIKPsssANAIysL SwissProt Entrez-Gene
Orthologous residues
CBL (human): S669‑p, CBL (mouse): S667‑p, CBL (rat): S668‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y674-p - CBL (human)
Modsite: sssANAIysLAARPL SwissProt Entrez-Gene
Orthologous residues
CBL (human): Y674‑p, CBL (mouse): Y672‑p, CBL (rat): Y673‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y149-p - CD3D (human)
Modsite: LLRNDQVyQPLRDRD SwissProt Entrez-Gene
Orthologous residues
CD3D (human): Y149‑p, CD3D (mouse): Y149‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y160-p - CD3D (human)
Modsite: RDRDDAQysHLGGNW SwissProt Entrez-Gene
Orthologous residues
CD3D (human): Y160‑p, CD3D (mouse): Y160‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y199-p - CD3E (human)
Modsite: RKGQRDLysGLNQRR SwissProt Entrez-Gene
Orthologous residues
CD3E (human): Y199‑p, CD3E (mouse): Y181‑p, CD3E (rat): Y180‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y83-p - CD3Z (human)
Modsite: NLGRREEyDVLDkRR SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y83‑p, CD3Z iso3 (human): Y83‑p, CD3Z (mouse): Y83‑p, CD3Z iso2 (mouse): Y83‑p, CD3Z (rat): Y83‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y111-p - CD3Z (human)
Modsite: kNPQEGLyNELQkDk SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y111‑p, CD3Z iso3 (human): Y110‑p, CD3Z (mouse): Y111‑p, CD3Z iso2 (mouse): Y111‑p, CD3Z (rat): Y111‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y123-p - CD3Z (human)
Modsite: kDkMAEAysEIGMkG SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y123‑p, CD3Z iso3 (human): Y122‑p, CD3Z (mouse): Y123‑p, CD3Z iso2 (mouse): Y123‑p, CD3Z (rat): Y123‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y142-p - CD3Z (human)
Modsite: GkGHDGLyQGLstAt SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y142‑p, CD3Z iso3 (human): Y141‑p, CD3Z (mouse): Y142‑p, CD3Z iso2 (mouse): Y142‑p, CD3Z (rat): Y142‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S439-p - CD5 (human)
Modsite: NHtAtVRsHAENPtA SwissProt Entrez-Gene
Orthologous residues
CD5 (human): S439‑p, CD5 (mouse): S438‑p, CD5 (rat): S435‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y453-p - CD5 (human)
Modsite: AsHVDNEysQPPRNs SwissProt Entrez-Gene
Orthologous residues
CD5 (human): Y453‑p, CD5 (mouse): Y452‑p, CD5 (rat): Y449‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S460-p - CD5 (human)
Modsite: ysQPPRNsHLSAyPA SwissProt Entrez-Gene
Orthologous residues
CD5 (human): S460‑p, CD5 (mouse): S459‑p, CD5 (rat): S456‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y1068-p - CHD-1 (human)
Modsite: QkELEEIyMLPRMRN SwissProt Entrez-Gene
Orthologous residues
CHD‑1 (human): Y1068‑p, CHD‑1 iso2 (human): Y1068‑p, CHD‑1 (mouse): Y1066‑p, CHD‑1 (rat): Y1066‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y421-p - Cortactin (human)
Modsite: rLPssPVyEDAAsFK SwissProt Entrez-Gene
Orthologous residues
Cortactin (human): Y421‑p, Cortactin iso2 (human): Y384‑p, Cortactin iso3 (human): Y384‑p, Cortactin (mouse): Y421‑p, Cortactin (rat): Y383‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y449-p - DOK1 (human)
Modsite: KsHNsALysQVQKSG SwissProt Entrez-Gene
Orthologous residues
DOK1 (human): Y449‑p, DOK1 iso3 (human): Y310‑p, DOK1 (mouse): Y450‑p, DOK1 (rat): Y448‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y299-p - DOK2 (human)
Modsite: PRGQEGEyAVPFDAV SwissProt Entrez-Gene
Orthologous residues
DOK2 (human): Y299‑p, DOK2 (mouse): Y304‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y259-p - GAB1 (human)
Modsite: AsVDssLyNLPRSys SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): Y259‑p, GAB1 iso2 (human): Y259‑p, GAB1 (mouse): Y259‑p, GAB1 (rat): Y258‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

S266-p - GAB1 (human)
Modsite: yNLPRSysHDVLPKV SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): S266‑p, GAB1 iso2 (human): S266‑p, GAB1 (mouse): S266‑p, GAB1 (rat): S265‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y266-p - GAB2 (human)
Modsite: TEFRDstyDLPRSLA SwissProt Entrez-Gene
Orthologous residues
GAB2 (human): Y266‑p, GAB2 iso2 (human): Y228‑p, GAB2 (mouse): Y263‑p, GAB2 (rat): Y263‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

T262-p - GADS (human)
Modsite: ALMHRRHtDPVQLQA SwissProt Entrez-Gene
Orthologous residues
GADS (human): T262‑p, GADS (mouse): T254‑p, GADS (rat): T258‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y198-p - HS1 (human)
Modsite: AkGFGGQyGIQKDRV SwissProt Entrez-Gene
Orthologous residues
HS1 (human): Y198‑p, HS1 (mouse): Y198‑p, HS1 (rat): Y198‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y301-p - LPP (human)
Modsite: GRyyEGyyAAGPGyG SwissProt Entrez-Gene
Orthologous residues
LPP (human): Y301‑p, LPP (mouse): Y302‑p, LPP (rat): F298‑p, LPP (cow): C303‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y478-p - plakophilin 4 (human)
Modsite: ALNttAtyAEPyRPI SwissProt Entrez-Gene
Orthologous residues
plakophilin 4 (human): Y478‑p, plakophilin 4 iso2 (human): Y478‑p, plakophilin 4 (mouse): Y477‑p, plakophilin 4 iso2 (mouse): Y477‑p, plakophilin 4 iso3 (mouse): Y475‑p, plakophilin 4 (rat): Y477‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y482-p - plakophilin 4 (human)
Modsite: tAtyAEPyRPIQyRV SwissProt Entrez-Gene
Orthologous residues
plakophilin 4 (human): Y482‑p, plakophilin 4 iso2 (human): Y482‑p, plakophilin 4 (mouse): Y481‑p, plakophilin 4 iso2 (mouse): Y481‑p, plakophilin 4 iso3 (mouse): Y479‑p, plakophilin 4 (rat): Y481‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y579-p - Pyk2 (human)
Modsite: RyIEDEDyykAsVTR SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y579‑p, Pyk2 iso2 (human): Y579‑p, Pyk2 (mouse): Y579‑p, Pyk2 (rat): Y579‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y580-p - Pyk2 (human)
Modsite: yIEDEDyykAsVTRL SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y580‑p, Pyk2 iso2 (human): Y580‑p, Pyk2 (mouse): Y580‑p, Pyk2 (rat): Y580‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y427-p - SHC1 (human)
Modsite: ELFDDPsyVNVQNLD SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): Y427‑p, SHC1 iso2 (human): Y317‑p, SHC1 iso3 (human): Y272‑p, SHC1 iso6 (human): Y428‑p, SHC1 iso7 (human): Y318‑p, SHC1 (mouse): Y423‑p, SHC1 iso2 (mouse): Y313‑p, SHC1 iso3 (mouse): Y268‑p, SHC1 (rat): Y423‑p, SHC1 iso2 (rat): Y313‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y671-p - SHIP-2 (human)
Modsite: ERGSRDTyAWHKQKP SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): Y671‑p, SHIP‑2 iso2 (human): Y429‑p, SHIP‑2 (mouse): Y672‑p, SHIP‑2 (rat): Y672‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y886-p - SHIP-2 (human)
Modsite: LGtRERLyEWIsIDK SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): Y886‑p, SHIP‑2 iso2 (human): Y644‑p, SHIP‑2 (mouse): Y887‑p, SHIP‑2 (rat): Y887‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y986-p - SHIP-2 (human)
Modsite: NsFNNPAyyVLEGVP SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): Y986‑p, SHIP‑2 iso2 (human): Y744‑p, SHIP‑2 (mouse): Y987‑p, SHIP‑2 (rat): Y987‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

S1003-p - SHIP-2 (human)
Modsite: LLPPEPPsPARAPVP SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): S1003‑p, SHIP‑2 iso2 (human): S761‑p, SHIP‑2 (mouse): S1004‑p, SHIP‑2 (rat): S1004‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

S1104-p - SHIP-2 (human)
Modsite: PPLPPGPsPASTFLG SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): S1104‑p, SHIP‑2 iso2 (human): S862‑p, SHIP‑2 (mouse): S1105‑p, SHIP‑2 (rat): S1105‑p

Y1135-p - SHIP-2 (human)
Modsite: KtLsEVDyAPAGPAr SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): Y1135‑p, SHIP‑2 iso2 (human): Y893‑p, SHIP‑2 (mouse): Y1136‑p, SHIP‑2 (rat): Y1136‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y1162-p - SHIP-2 (human)
Modsite: PRGLPsDyGRPLsFP SwissProt Entrez-Gene
Orthologous residues
SHIP‑2 (human): Y1162‑p, SHIP‑2 iso2 (human): Y920‑p, SHIP‑2 (mouse): Y1161‑p, SHIP‑2 (rat): Y1161‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y348-p - Syk (human)
Modsite: LPMDtEVyEsPyADP SwissProt Entrez-Gene
Orthologous residues
Syk (human): Y348‑p, Syk iso2 (human): Y325‑p, Syk (mouse): Y342‑p, Syk (rat): Y342‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y352-p - Syk (human)
Modsite: tEVyEsPyADPEEIR SwissProt Entrez-Gene
Orthologous residues
Syk (human): Y352‑p, Syk iso2 (human): Y329‑p, Syk (mouse): Y346‑p, Syk (rat): Y346‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human

Y292-p - ZAP70 (human)
Modsite: DtLNsDGytPEPARI SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y292‑p, ZAP70 (mouse): Y290‑p, ZAP70 (rat): Y290‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y315-p - ZAP70 (human)
Modsite: MPMDtsVyEsPysDP SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y315‑p, ZAP70 (mouse): Y314‑p, ZAP70 (rat): Y310‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y319-p - ZAP70 (human)
Modsite: tsVyEsPysDPEELk SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y319‑p, ZAP70 (mouse): Y318‑p, ZAP70 (rat): Y314‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y492-p - ZAP70 (human)
Modsite: ALGADDsyytARsAG SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y492‑p, ZAP70 (mouse): Y491‑p, ZAP70 (rat): Y487‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y493-p - ZAP70 (human)
Modsite: LGADDsyytARsAGk SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y493‑p, ZAP70 (mouse): Y492‑p, ZAP70 (rat): Y488‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y185-p - Abl (mouse)
Modsite: TASDGKLyVSSESRF SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y185‑p, Abl iso2 (human): Y204‑p, Abl (mouse): Y185‑p, Abl iso4 (mouse): Y204‑p, Abl (rat): Y185‑p, Abl iso2 (rat): Y204‑p

Y226-p - Abl (mouse)
Modsite: KRNKPTIyGVSPNyD SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y226‑p, Abl iso2 (human): Y245‑p, Abl (mouse): Y226‑p, Abl iso4 (mouse): Y245‑p, Abl (rat): Y226‑p, Abl iso2 (rat): Y245‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y264-p - Abl (mouse)
Modsite: yEGVWKKySLTVAVK SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y264‑p, Abl iso2 (human): Y283‑p, Abl (mouse): Y264‑p, Abl iso4 (mouse): Y283‑p, Abl (rat): Y264‑p, Abl iso2 (rat): Y283‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

T394-p - Abl (mouse)
Modsite: LMTGDTytAHAGAKF SwissProt Entrez-Gene
Orthologous residues
Abl (human): T394‑p, Abl iso2 (human): T413‑p, Abl (mouse): T394‑p, Abl iso4 (mouse): T413‑p, Abl (rat): T394‑p, Abl iso2 (rat): T413‑p

Y469-p - Abl (mouse)
Modsite: EGCPEKVyELMRACW SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y469‑p, Abl iso2 (human): Y488‑p, Abl (mouse): Y469‑p, Abl iso4 (mouse): Y488‑p, Abl (rat): Y469‑p, Abl iso2 (rat): Y488‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y91-p - Cas-L (mouse)
Modsite: TFGQQKLyQVPNsQA SwissProt Entrez-Gene
Orthologous residues
Cas‑L (human): Y92‑p, Cas‑L iso3 (human): Y92‑p, Cas‑L (mouse): Y91‑p, Cas‑L (rat): Y91‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y176-p - Cas-L (mouse)
Modsite: SRYQKDVyDVPPsHs SwissProt Entrez-Gene
Orthologous residues
Cas‑L (human): Y177‑p, Cas‑L iso3 (human): Y177‑p, Cas‑L (mouse): Y176‑p, Cas‑L (rat): Y176‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y188-p - Cas-L (mouse)
Modsite: sHsTQGVyDIPPSsV SwissProt Entrez-Gene
Orthologous residues
Cas‑L (human): Y189‑p, Cas‑L iso3 (human): Y189‑p, Cas‑L (mouse): Y188‑p, Cas‑L (rat): Y188‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y672-p - CBL (mouse)
Modsite: SssANAIysLAARPL SwissProt Entrez-Gene
Orthologous residues
CBL (human): Y674‑p, CBL (mouse): Y672‑p, CBL (rat): Y673‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

S692-p - CBL (mouse)
Modsite: PPGEQGEsEEDtEyM SwissProt Entrez-Gene
Orthologous residues
CBL (human): G694‑p, CBL (mouse): S692‑p, CBL (rat): S693‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y698-p - CBL (mouse)
Modsite: EsEEDtEyMTPTsRP SwissProt Entrez-Gene
Orthologous residues
CBL (human): Y700‑p, CBL (mouse): Y698‑p, CBL (rat): Y699‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y321-p - DYRK1A (mouse)
Modsite: LGQRIyQyIQsRFYR SwissProt Entrez-Gene
Orthologous residues
DYRK1A (human): Y321‑p, DYRK1A iso2 (human): Y312‑p, DYRK1A iso4 (human): Y321‑p, DYRK1A (mouse): Y321‑p, DYRK1A (rat): Y321‑p, DYRK1A (rabbit):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y273-p - SHEP1 (mouse)
Modsite: VVKAGESyTHIRYLF SwissProt Entrez-Gene
Orthologous residues
SHEP1 (human): Y278‑p, SHEP1 iso2 (human): Y121‑p, SHEP1 (mouse): Y273‑p, SHEP1 (rat): Y273‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse

Y580-p - SHP-2 (mouse)
Modsite: REDsARVyENVGLMQ SwissProt Entrez-Gene
Orthologous residues
SHP‑2 (human): Y580‑p, SHP‑2 iso1 (human): Y584‑p, SHP‑2 (mouse): Y580‑p, SHP‑2 (rat): Y584‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  32D (myeloid) [BCR-ABL1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  mouse