Sahin B, et al. (2008) Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Eur J Pharmacol 581, 270-5 18190909

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T75-p - DARPP-32 (mouse) ▲

Modsite: RPNPCAYtPPSLKAV SwissProt Entrez-Gene Orthologous residues DARPP‑32 (human): T75‑p, DARPP‑32 iso2 (human): T39‑p, DARPP‑32 (mouse): T75‑p, DARPP‑32 (rat): T75‑p, DARPP‑32 (cow): T75‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes phorbol_ester decrease

S6-p - PPP1R1A (mouse) ▲

Modsite: __MEPDNsPRKIQFT SwissProt Entrez-Gene Orthologous residues PPP1R1A (human): S6‑p, PPP1R1A (mouse): S6‑p, PPP1R1A (rat): S6‑p, PPP1R1A (rabbit): S6‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes phorbol_ester decrease

S67-p - PPP1R1A (mouse) ▲

Modsite: LKSTLsMsPRQRKKM SwissProt Entrez-Gene Orthologous residues PPP1R1A (human): S67‑p, PPP1R1A (mouse): S67‑p, PPP1R1A (rat): S67‑p, PPP1R1A (rabbit): S67‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes phorbol_ester decrease Ro-32-0432 phorbol_ester inhibit treatment-induced decrease