Benn SC, et al. (2002) Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival. Neuron 36, 45-56 12367505

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S15-p - HSP27 (human) ▲

Modsite: FsLLrGPsWDPFrDW SwissProt Entrez-Gene Orthologous residues HSP27 (human): S15‑p, HSP27 (mouse): S15‑p, HSP27 (rat): S15‑p, HSP27 (pig): S15‑p, HSP27 (hamster): S15‑p, HSP27 (chicken): S15‑p, HSP27 (dog): S15‑p, HSP27 (cow): S15‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Cellular systems studied:  cell lines, primary cells, primary cultured cells Species studied:  human, rat Downstream Regulation Effect of modification (process):  apoptosis, inhibited Comments:  triple mutant (S15A/S78A/S82A)

S78-p - HSP27 (human) ▲

Modsite: PAysRALsRQLssGV SwissProt Entrez-Gene Orthologous residues HSP27 (human): S78‑p, HSP27 (mouse): N82‑p, HSP27 (rat): N82‑p, HSP27 (pig): S80‑p, HSP27 (hamster): N86‑p, HSP27 (chicken): S77‑p, HSP27 (dog): S82‑p, HSP27 (cow): S74‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Cellular systems studied:  cell lines, primary cells, primary cultured cells Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes nerve_damage increase Downstream Regulation Effect of modification (process):  apoptosis, inhibited Comments:  triple mutant (S15A/S78A/S82A)

S82-p - HSP27 (human) ▲

Modsite: RALsRQLssGVsEIr SwissProt Entrez-Gene Orthologous residues HSP27 (human): S82‑p, HSP27 (mouse): S86‑p, HSP27 (rat): S86‑p, HSP27 (pig): S84‑p, HSP27 (hamster): S90‑p, HSP27 (chicken): S80‑p, HSP27 (dog): S86‑p, HSP27 (cow): S78‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Cellular systems studied:  cell lines, primary cells, primary cultured cells Species studied:  human, rat Downstream Regulation Effect of modification (process):  apoptosis, inhibited Comments:  triple mutant (S15A/S78A/S82A)