Eaton P, Fuller W, Bell JR, Shattock MJ (2001) AlphaB crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart. J Mol Cell Cardiol 33, 1659-71 11549345

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S45-p - CRYAB (rat) ▲

Modsite: FSTATSLsPFYLRPP SwissProt Entrez-Gene Orthologous residues CRYAB (human): S45‑p, CRYAB (mouse): S45‑p, CRYAB (rat): S45‑p, CRYAB (rabbit): S45‑p, CRYAB (pig): S45‑p, CRYAB (cow): S45‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ERK2 (human) pharmacological inhibitor of upstream enzyme KINASE ERK1 (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ischemia increase genistein ischemia inhibit treatment-induced increase SB203580 ischemia inhibit treatment-induced increase bisindolylmaleimide ischemia inhibit treatment-induced increase PD98059 ischemia inhibit treatment-induced increase anisomycin no change compared to control phenylephrine increase phorbol_ester increase

S59-p - CRYAB (rat) ▲

Modsite: PSFLRAPsWIDTGLS SwissProt Entrez-Gene Orthologous residues CRYAB (human): S59‑p, CRYAB (mouse): S59‑p, CRYAB (rat): S59‑p, CRYAB (rabbit): S59‑p, CRYAB (pig): S59‑p, CRYAB (cow): S59‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ischemia increase genistein ischemia inhibit treatment-induced increase SB203580 ischemia inhibit treatment-induced increase bisindolylmaleimide ischemia inhibit treatment-induced increase PD98059 ischemia no effect upon treatment-induced increase anisomycin increase phenylephrine increase phorbol_ester increase