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Home > Curated Information Page > PubMed Id: 16464862
Lewthwaite JC, et al. (2006) A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. J Biol Chem 281, 11011-8 16464862
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
mechanical stress increase strain
SB203580 mechanical stress augment treatment-induced increase early (20 and 60 minutes)
SB203580 mechanical stress inhibit treatment-induced increase later effects (6 and 24 hour)
SB202190 mechanical stress augment treatment-induced increase early
SB202190 mechanical stress inhibit treatment-induced increase later effects
U0126 mechanical stress inhibit treatment-induced increase At both early and later (20 minute and 24 hours) time points
FGF2 increase
SB203580 FGF2 no effect upon treatment-induced increase
vanadate increase
SB203580 vanadate no effect upon treatment-induced increase

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
mechanical stress increase strain
SB203580 mechanical stress augment treatment-induced increase early (20 and 60 minutes)
SB203580 mechanical stress inhibit treatment-induced increase later effects (6 and 24 hour)
SB202190 mechanical stress augment treatment-induced increase early
SB202190 mechanical stress inhibit treatment-induced increase later effects
U0126 mechanical stress inhibit treatment-induced increase At both early and later (20 minute and 24 hours) time points
FGF2 increase
SB203580 FGF2 no effect upon treatment-induced increase
vanadate increase
SB203580 vanadate no effect upon treatment-induced increase

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF2 increase
SB203580 FGF2 no effect upon treatment-induced increase
vanadate increase
SB203580 vanadate no effect upon treatment-induced increase
mechanical stress increase strain
SB203580 mechanical stress augment treatment-induced increase early (20 and 60 minutes)
SB203580 mechanical stress inhibit treatment-induced increase later effects (6 and 24 hour)
SB202190 mechanical stress augment treatment-induced increase early
SB202190 mechanical stress inhibit treatment-induced increase later effects
U0126 mechanical stress inhibit treatment-induced increase At both early and later (20 minute and 24 hours) time points

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF2 increase
SB203580 FGF2 no effect upon treatment-induced increase
vanadate increase
SB203580 vanadate no effect upon treatment-induced increase
mechanical stress increase strain
SB203580 mechanical stress augment treatment-induced increase early (20 and 60 minutes)
SB203580 mechanical stress inhibit treatment-induced increase later effects (6 and 24 hour)
SB202190 mechanical stress augment treatment-induced increase early
SB202190 mechanical stress inhibit treatment-induced increase later effects
U0126 mechanical stress inhibit treatment-induced increase At both early and later (20 minute and 24 hours) time points

T325-p - Fos (human)
Modsite: TELEPLCtPVVTCtP SwissProt Entrez-Gene
Orthologous residues
Fos (human): T325‑p, Fos (mouse): T325‑p, Fos (rat): T325‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
mechanical stress increase
SB203580 mechanical stress augment treatment-induced increase early (20 minutes after strain)
SB203580 mechanical stress inhibit treatment-induced increase later (24 hours after strain)

S218-p - MEK1 (human)
Modsite: VsGQLIDsMANsFVG SwissProt Entrez-Gene
Orthologous residues
MEK1 (human): S218‑p, MEK1 iso2 (human): S192‑p, MEK1 (mouse): S218‑p, MEK1 (rat): S218‑p, MEK1 (rabbit): S218‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SB202190 increase at 24 hours after mechanical strain

S222-p - MEK1 (human)
Modsite: LIDsMANsFVGtRSY SwissProt Entrez-Gene
Orthologous residues
MEK1 (human): S222‑p, MEK1 iso2 (human): S196‑p, MEK1 (mouse): S222‑p, MEK1 (rat): S222‑p, MEK1 (rabbit): S222‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SB202190 increase at 24 hours after mechanical strain

S222-p - MEK2 (human)
Modsite: VsGQLIDsMANsFVG SwissProt Entrez-Gene
Orthologous residues
MEK2 (human): S222‑p, MEK2 (mouse): S222‑p, MEK2 (rat): S222‑p, MEK2 (chicken): S220‑p, MEK2 (cow): S222‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SB202190 increase at 24 hours after mechanical strain

S226-p - MEK2 (human)
Modsite: LIDsMANsFVGtRSY SwissProt Entrez-Gene
Orthologous residues
MEK2 (human): S226‑p, MEK2 (mouse): S226‑p, MEK2 (rat): S226‑p, MEK2 (chicken): S224‑p, MEK2 (cow): S226‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SB202190 increase at 24 hours after mechanical strain

T180-p - P38A (human)
Modsite: RHtDDEMtGyVAtRW SwissProt Entrez-Gene
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
mechanical stress no change compared to control strain
U0126 mechanical stress increase At both early and later (20 minute and 24 hours) time points
U0126 increase At both early and later (20 minute and 24 hours) time points
FGF2 no change compared to control
vanadate increase

Y182-p - P38A (human)
Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
mechanical stress no change compared to control strain
U0126 mechanical stress increase At both early and later (20 minute and 24 hours) time points
U0126 increase At both early and later (20 minute and 24 hours) time points
FGF2 no change compared to control
vanadate increase