Curated Information
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Home > Curated Information Page > PubMed Id: 20153492
Jensen J, et al. (2011) Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle. Metabolism 60, 215-26 20153492
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T308-p - Akt1 (human)
Modsite: kDGAtMKtFCGtPEy SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T308‑p, Akt1 iso2 (human): T246‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin increase
insulin racepinefrine increase

S473-p - Akt1 (human)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin increase
insulin racepinefrine increase

S9-p - GSK3B (human)
Modsite: SGRPRttsFAEsCkP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin increase
insulin racepinefrine increase

S8-p - GYS1 (human)
Modsite: MPLNRtLsMssLPGL SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S8‑p, GYS1 iso2 (human): S8‑p, GYS1 (mouse): S8‑p, GYS1 (rat): S8‑p, GYS1 (rabbit): S8‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin no change compared to control
insulin racepinefrine no change compared to control

S641-p - GYS1 (human)
Modsite: YRyPRPAsVPPsPsL SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S641‑p, GYS1 iso2 (human): S577‑p, GYS1 (mouse): S641‑p, GYS1 (rat): S641‑p, GYS1 (rabbit): S641‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine increase
insulin decrease
insulin racepinefrine no change compared to control

S645-p - GYS1 (human)
Modsite: RPAsVPPsPsLsRHs SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S645‑p, GYS1 iso2 (human): S581‑p, GYS1 (mouse): S645‑p, GYS1 (rat): S645‑p, GYS1 (rabbit): S645‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin decrease
insulin racepinefrine decrease

S649-p - GYS1 (human)
Modsite: VPPsPsLsRHssPHQ SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S649‑p, GYS1 iso2 (human): S585‑p, GYS1 (mouse): S649‑p, GYS1 (rat): S649‑p, GYS1 (rabbit): S649‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin decrease
insulin racepinefrine decrease

S653-p - GYS1 (human)
Modsite: PsLsRHssPHQsEDE SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S653‑p, GYS1 iso2 (human): S589‑p, GYS1 (mouse): S653‑p, GYS1 (rat): S653‑p, GYS1 (rabbit): S653‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin decrease
insulin racepinefrine decrease

S657-p - GYS1 (human)
Modsite: RHssPHQsEDEEDPR SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S657‑p, GYS1 iso2 (human): S593‑p, GYS1 (mouse): S657‑p, GYS1 (rat): S657‑p, GYS1 (rabbit): S657‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
racepinefrine no change compared to control
insulin decrease
insulin racepinefrine decrease