Singh M, Castillo D, Patel CV, Patel RC (2011) Stress-Induced Phosphorylation of PACT Reduces Its Interaction with TRBP and Leads to PKR Activation. Biochemistry 50, 4550-60 21526770

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S246-p - PACT (human) ▲

Modsite: TDyIQLLsEIAKEQG SwissProt Entrez-Gene Orthologous residues PACT (human): S246‑p, PACT (mouse): S246‑p, PACT (rat): S246‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human, yeast Downstream Regulation Effect of modification (function):  enzymatic activity, induced Effect of modification (process):  apoptosis, induced Comments:  PKR enzymatic activity induced

S287-p - PACT (human) ▲

Modsite: PITVCHGsGISCGNA SwissProt Entrez-Gene Orthologous residues PACT (human): S287‑p, PACT (mouse): S287‑p, PACT (rat): S287‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human, yeast Downstream Regulation Effect of modification (function):  enzymatic activity, induced, molecular association, regulation Effect of modification (process):  apoptosis, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TRBP (human) Disrupts yeast two-hybrid, co-immunoprecipitation Comments:  PKR enzymatic activity induced