Curated Information
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Home > Curated Information Page > PubMed Id: 16434614
D'Astous M, et al. (2006) Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Mol Pharmacol 69, 1492-8 16434614
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S473-p - Akt1 (mouse)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MPTP increase
estradiol MPTP augment treatment-induced increase 17B-estradiol
estradiol MPTP augment treatment-induced increase PPT
estradiol MPTP inhibit treatment-induced increase delta5-diol
estradiol increase 17B-estradiol
estradiol increase PPT
estradiol increase delta5-diol

S9-p - GSK3B (mouse)
Modsite: SGRPRttsFAEsCKP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MPTP decrease
estradiol MPTP inhibit treatment-induced decrease 17B-estradiol
estradiol MPTP inhibit treatment-induced increase PPT
estradiol MPTP inhibit treatment-induced decrease delta5-diol
estradiol increase 17B-estradiol
estradiol increase PPT
estradiol increase delta5-diol