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Home > Curated Information Page > PubMed Id: 21215704
Chandarlapaty S, et al. (2011) AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 19, 58-71 21215704
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S65-p - 4E-BP1 (human)
Modsite: FLMECrNsPVtktPP SwissProt Entrez-Gene
Orthologous residues
4E‑BP1 (human): S65‑p, 4E‑BP1 (mouse): S64‑p, 4E‑BP1 (rat): S64‑p, 4E‑BP1 (fruit fly): S65‑p, 4E‑BP1 (cow): S65‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

T308-p - Akt1 (human)
Modsite: kDGAtMKtFCGtPEy SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T308‑p, Akt1 iso2 (human): T246‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

S473-p - Akt1 (human)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y1092-p - EGFR (human)
Modsite: tFLPVPEyINQsVPk SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1092‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1092‑p, EGFR (rat): Y1091‑p, EGFR (pig): Y1091‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y877-p - HER2 (human)
Modsite: LDIDEtEyHADGGkV SwissProt Entrez-Gene
Orthologous residues
HER2 (human): Y877‑p, HER2 iso2 (human): Y267‑p, HER2 iso5 (human): Y847‑p, HER2 (mouse): Y878‑p, HER2 (rat): Y879‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y1221-p - HER2 (human)
Modsite: sPAFDNLyyWDQDPP SwissProt Entrez-Gene
Orthologous residues
HER2 (human): Y1221‑p, HER2 iso2 (human): Y611‑p, HER2 iso5 (human): Y1191‑p, HER2 (mouse): Y1222‑p, HER2 (rat): Y1223‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y1197-p - HER3 (human)
Modsite: EEDEDEEyEyMNRRR SwissProt Entrez-Gene
Orthologous residues
HER3 (human): Y1197‑p, HER3 iso2 (human): , HER3 iso4 (human): Y1138‑p, HER3 (mouse): Y1194‑p, HER3 (rat): Y1194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y1289-p - HER3 (human)
Modsite: CPAsEQGyEEMRAFQ SwissProt Entrez-Gene
Orthologous residues
HER3 (human): Y1289‑p, HER3 iso2 (human): , HER3 iso4 (human): Y1230‑p, HER3 (mouse): Y1286‑p, HER3 (rat): Y1286‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

Y1284-p - HER4 (human)
Modsite: IVAENPEyLSEFSLK SwissProt Entrez-Gene
Orthologous residues
HER4 (human): Y1284‑p, HER4 iso2 (human): Y1274‑p, HER4 iso3 (human): Y1268‑p, HER4 iso4 (human): Y1258‑p, HER4 (mouse): Y1284‑p, HER4 (rat): Y1284‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

T412-p - p70S6K (human)
Modsite: NQVFLGFtyVAPsVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

T246-p - PRAS40 (human)
Modsite: LPRPRLNtsDFQkLK SwissProt Entrez-Gene
Orthologous residues
PRAS40 (human): T246‑p, PRAS40 iso2 (human): T116‑p, PRAS40 iso3 (human): T266‑p, PRAS40 (mouse): T247‑p, PRAS40 (rat): T247‑p, PRAS40 (cow): T246‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  breast cancer, lung cancer
Relevant cell lines - cell types - tissues:  BT-474 (breast cell), NCI-H292 (pulmonary), SKBr3 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human