Kwon H, et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J Cell Mol Med 15, 888-908 20455999

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Y19-p - caveolin-2 (human) ▲

Modsite: LFMDDDsysHHsGLE SwissProt Entrez-Gene Orthologous residues caveolin‑2 (human): Y19‑p, caveolin‑2 iso2 (human): Y6‑p, caveolin‑2 iso3 (human): Y19‑p, caveolin‑2 (mouse): Y19‑p, caveolin‑2 (rat): Y19‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  COS7 (fibroblast), HIRcB (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes insulin increase IGF-1 no change compared to control Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation, phosphorylation Effect of modification (process):  signaling pathway regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ERK1 (human) Induces co-immunoprecipitation, microscopy-colocalization Comments:  Regulation of insulin signaling and induces ERK phosphorylation.

Y27-p - caveolin-2 (human) ▲
Modsite: sHHsGLEyADPEKFA SwissProt Entrez-Gene Orthologous residues caveolin‑2 (human): Y27‑p, caveolin‑2 iso2 (human): Y14‑p, caveolin‑2 iso3 (human): Y27‑p, caveolin‑2 (mouse): Y27‑p, caveolin‑2 (rat): Y27‑p