Curated Information
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Home > Curated Information Page > PubMed Id: 21486282
Zhang DY, et al. (2011) Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR) 2.3 channel, stably expressed in HEK 293 cells. Br J Pharmacol 164, 1469-78 21486282
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y234-p - HIR (human)
Modsite: YMTQEGEyLPLDQRD SwissProt Entrez-Gene
Orthologous residues
HIR (human): Y234‑p, HIR (mouse): Y233‑p, HIR (rat): Y234‑p
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE EGFR (human) activation of upstream enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
vanadate EGF augment treatment-induced increase
AG1295 decrease
AG556 EGF inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  activity, induced
Comments:  increased channel current