Curated Information
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Home > Curated Information Page > PubMed Id: 12403770
Pollok-Kopp B, Schwarze K, Baradari VK, Oppermann M (2003) Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem 278, 2190-8 12403770
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S336-p - CCR5 (human)
Modsite: QEAPERAssVyTRst SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S336‑p, CCR5 (mouse): S338‑p, CCR5 (rat): S338‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase
bisindolylmaleimide phorbol_ester inhibit treatment-induced increase
PTX phorbol_ester no effect upon treatment-induced increase
RANTES increase
bisindolylmaleimide RANTES inhibit treatment-induced increase
PTX RANTES inhibit treatment-induced increase

S349-p - CCR5 (human)
Modsite: stGEQEIsVGL____ SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S349‑p, CCR5 (mouse): S351‑p, CCR5 (rat): S351‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester no change compared to control
RANTES increase
bisindolylmaleimide RANTES no effect upon treatment-induced increase
PTX RANTES no effect upon treatment-induced increase