Curated Information
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Home > Curated Information Page > PubMed Id: 12427729
Okada S, Ouchi T (2003) Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. J Biol Chem 278, 2015-20 12427729
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S988-p - BRCA1 (human)
Modsite: PPLFPIksFVKTKCK SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S988‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S988‑p, BRCA1 (mouse): S971‑p, BRCA1 (rat): S975‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase Ionizing radiation induces phosphorylation in S phase and G2/M phase of the cell cycle.
UV increase UV radiation induces phosphorylation during S phase of the cell cycle.
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  UV- or IR-induced phosphorylation of S988 correlates with relocalization to the perinuclear region during S phase.

S1423-p - BRCA1 (human)
Modsite: AVLEQHGsQPSNSYP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1423‑p, BRCA1 iso6 (human): S320‑p, BRCA1 iso7 (human): S1423‑p, BRCA1 (mouse): N1379‑p, BRCA1 (rat): S1380‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase Ionizing radiation induces phosphorylation in G2/M phase of the cell cycle.

S1497-p - BRCA1 (human)
Modsite: EPGVERssPsKCPsL SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1497‑p, BRCA1 iso6 (human): S393‑p, BRCA1 iso7 (human): S1518‑p, BRCA1 (mouse): S1454‑p, BRCA1 (rat): S1455‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

S1524-p - BRCA1 (human)
Modsite: LQNRNYPsQEELIKV SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1524‑p, BRCA1 iso6 (human): S420‑p, BRCA1 iso7 (human): S1545‑p, BRCA1 (mouse): S1481‑p, BRCA1 (rat): S1482‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  breast cancer, breast adenocarcinoma, breast ductal carcinoma
Relevant cell lines - cell types - tissues:  293 (epithelial), HCC1937 (breast cell), MCF-7 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase Ionizing radiation induces phosphorylation in S phase of the cell cycle.