Wang B, et al. (2023) IDH1 K224 acetylation promotes colorectal cancer via miR-9-5p/NHE1 axis-mediated regulation of acidic microenvironment. iScience 26, 107206 37456829

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K224-ac - IDH1 (human) ▲

Modsite: KKyDGRFkDIFQEIy SwissProt Entrez-Gene Orthologous residues IDH1 (human): K224‑ac, IDH1 (mouse): K224‑ac, IDH1 (rat): K224‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma Relevant cell lines - cell types - tissues:  HCT116 (intestinal), SW480 (intestinal) Cellular systems studied:  cell lines, tissue Species studied:  human, mouse Downstream Regulation Effect of modification (process):  carcinogenesis, induced, cell growth, induced, cell motility, induced Comments:  regulation of the acidic microenvironment of CRC cells; K224R cells had a significantly higher pH value than that of the WT cells; regulates expression of miRNA in CRC cells; correlated with NHE1 expression, enhancing hydroxylation; expression of Ago2 and NHE1 protein inCRC cells and tissues Associated Diseases Diseases Alterations Comments colorectal carcinoma increased