Yue L, et al. (2023) TRIM24-Mediated Acetylation of STAT6 Suppresses Th2-Induced Allergic Rhinitis. Allergy Asthma Immunol Res 15, 603-613 37827979

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K383-ac - STAT6 (human) ▲

Modsite: TESVTEEkCAVLFSA SwissProt Entrez-Gene Orthologous residues STAT6 (human): K383‑ac, STAT6 iso2 (human): K209‑ac, STAT6 (mouse): K383‑ac, STAT6 (rat): K383‑ac Characterization Methods used to characterize site in vivo:  flow cytometry, immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  lymphocyte Cellular systems studied:  primary cells Species studied:  human, mouse Downstream Regulation Effect of modification (function):  acetylation, activity, inhibited Effect of modification (process):  transcription, altered Comments:  TRIM24 regulated STAT6-induced GATA3 expression through regulating the acetylation of STAT6

K383-ac - STAT6 (mouse) ▲

Modsite: TESVTEEkCAVLFST SwissProt Entrez-Gene Orthologous residues STAT6 (human): K383‑ac, STAT6 iso2 (human): K209‑ac, STAT6 (mouse): K383‑ac, STAT6 (rat): K383‑ac Characterization Methods used to characterize site in vivo:  flow cytometry, immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  lymphocyte Cellular systems studied:  primary cells Species studied:  human, mouse Downstream Regulation Effect of modification (function):  acetylation, activity, inhibited Effect of modification (process):  transcription, altered Comments:  TRIM24 regulated STAT6-induced GATA3 expression through regulating the acetylation of STAT6