Curated Information
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Home > Curated Information Page > PubMed Id: 37473874
Guillen-Quispe YN, et al. (2023) Oxygen-independent stabilization of HIF-2α in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. Free Radic Biol Med 207, 296-307 37473874
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S672-p - HIF2A (human)
Modsite: APLGPPVsPPHVSTF SwissProt Entrez-Gene
Orthologous residues
HIF2A (human): S672‑p, HIF2A (mouse): A676‑p, HIF2A (rat): T676‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), MDA-MB-231 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

S696-p - HIF2A (human)
Modsite: ARGPDVLsPAMVALS SwissProt Entrez-Gene
Orthologous residues
HIF2A (human): S696‑p, HIF2A (mouse): S700‑p, HIF2A (rat): S700‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), MDA-MB-231 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human

S790-p - HIF2A (human)
Modsite: PQPPSAIsPGENsKS SwissProt Entrez-Gene
Orthologous residues
HIF2A (human): S790‑p, HIF2A (mouse): S794‑p, HIF2A (rat): S794‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Disease tissue studied:  breast cancer, breast adenocarcinoma, breast cancer, triple negative
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), MCF-7 (breast cell), MDA-MB-231 (breast cell), MDA-MB-468 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein stabilization
Effect of modification (process):  carcinogenesis, induced, cell motility, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces co-immunoprecipitation, microscopy-colocalization