Howard TR, et al. (2021) The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle. mSystems 6, e0039721 34156286

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K110-ac - PYHIN1 (human) ▲

Modsite: PSKKTKQkEVYPATP SwissProt Entrez-Gene Orthologous residues PYHIN1 (human): K110‑ac, PYHIN1 iso2 (human): K101‑ac, PYHIN1 iso3 (human): K110‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  293 (epithelial), U2OS (bone cell) Cellular systems studied:  cell lines, primary cells Species studied:  human Downstream Regulation Effect of modification (function):  intracellular localization Comments:  induces partial cytoplasmic localization

K138-ac - PYHIN1 (human) ▲

Modsite: EETLGPQkRKKPsEE SwissProt Entrez-Gene Orthologous residues PYHIN1 (human): K138‑ac, PYHIN1 iso2 (human): K129‑ac, PYHIN1 iso3 (human): K138‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  293 (epithelial), U2OS (bone cell) Cellular systems studied:  cell lines, primary cells Species studied:  human Downstream Regulation Effect of modification (function):  intracellular localization Comments:  induces partial cytoplasmic localization