Kim DE, et al. (2023) PLK1-mediated phosphorylation of β-catenin enhances its stability and transcriptional activity for extracellular matrix remodeling in metastatic NSCLC. Theranostics 13, 1198-1216 36793862

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.

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S33-p - CTNNB1 (human) ▲

Modsite: QQQsyLDsGIHsGAT SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p, CTNNB1 (rabbit): S33‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

T41-p - CTNNB1 (human) ▲

Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p, CTNNB1 (rabbit): T41‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

S45-p - CTNNB1 (human) ▲

Modsite: GATtTAPsLsGkGNP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S45‑p, CTNNB1 (mouse): S45‑p, CTNNB1 (rat): S45‑p, CTNNB1 (rabbit): S45‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

S60-p - CTNNB1 (human) ▲

Modsite: EEEDVDTsQVLyEWE SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S60‑p, CTNNB1 (mouse): S60‑p, CTNNB1 (rat): S60‑p, CTNNB1 (rabbit): S60‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

S191-p - CTNNB1 (human) ▲

Modsite: sRHAIMRsPQMVsAI SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S191‑p, CTNNB1 (mouse): S191‑p, CTNNB1 (rat): S191‑p, CTNNB1 (rabbit): S191‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

T298-p - CTNNB1 (human) ▲

Modsite: VKFLAITtDCLQILA SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T298‑p, CTNNB1 (mouse): T298‑p, CTNNB1 (rat): T298‑p, CTNNB1 (rabbit): T298‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

S311-p - CTNNB1 (human) ▲

Modsite: LAYGNQEsKLIILAS SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S311‑p, CTNNB1 (mouse): S311‑p, CTNNB1 (rat): S311‑p, CTNNB1 (rabbit): S311‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PLK1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PLK1 (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, phospho-antibody Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation, protein stabilization Effect of modification (process):  carcinogenesis, induced, cell growth, induced, cell motility, induced, signaling pathway regulation, transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TCF4 (human) Not reported co-immunoprecipitation Comments:  induces ß-catenin/AP-1/PLK1 signaling

S352-p - CTNNB1 (human) ▲

Modsite: kVLSVCSsNkPAIVE SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S352‑p, CTNNB1 (mouse): S352‑p, CTNNB1 (rat): S352‑p, CTNNB1 (rabbit): S352‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

T371-p - CTNNB1 (human) ▲

Modsite: QALGLHLtDPsQRLV SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T371‑p, CTNNB1 (mouse): T371‑p, CTNNB1 (rat): T371‑p, CTNNB1 (rabbit): T371‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

S374-p - CTNNB1 (human) ▲

Modsite: GLHLtDPsQRLVQNC SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S374‑p, CTNNB1 (mouse): S374‑p, CTNNB1 (rat): S374‑p, CTNNB1 (rabbit): S374‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human

T384-p - CTNNB1 (human) ▲

Modsite: LVQNCLWtLRNLSDA SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T384‑p, CTNNB1 (mouse): T384‑p, CTNNB1 (rat): T384‑p, CTNNB1 (rabbit): T384‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human