Spel L, et al. (2022) CDC42 regulates PYRIN inflammasome assembly. Cell Rep 41, 111636 36384121

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S208-p - pyrin (human) ▲
Modsite: VRLRRNAssAGRLQG SwissProt Entrez-Gene Orthologous residues pyrin (human): S208‑p, pyrin (mouse): S205‑p, pyrin (rat): Q204‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  lymphoma Relevant cell lines - cell types - tissues:  U-937 (myeloid) Cellular systems studied:  cell lines Species studied:  human

S242-p - pyrin (human) ▲

Modsite: SGKMRPRsLEVTIST SwissProt Entrez-Gene Orthologous residues pyrin (human): S242‑p, pyrin (mouse): S241‑p, pyrin (rat): V238‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  leukemia, acute myelogenous leukemia, lymphoma Relevant cell lines - cell types - tissues:  THP1 (myeloid), U-937 (myeloid) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes Clostridioides difficile toxin B increase CDC42 (human) no change compared to control CDC42 KO has no effect CDC42 (human) increase Q61L mutant IPA-3 CDC42 (human) inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  activity, inhibited, molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays 14-3-3 beta (mouse) Induces co-immunoprecipitation