Magnotti F, et al. (2022) Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism. Cell Rep 41, 111472 36223753

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S208-p - pyrin (human) ▲

Modsite: VRLRRNAssAGRLQG SwissProt Entrez-Gene Orthologous residues pyrin (human): S208‑p, pyrin (mouse): S205‑p, pyrin (rat): Q204‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  lymphoma Relevant cell lines - cell types - tissues:  U-937 (myeloid) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  activity, inhibited

S242-p - pyrin (human) ▲

Modsite: SGKMRPRsLEVTIST SwissProt Entrez-Gene Orthologous residues pyrin (human): S242‑p, pyrin (mouse): S241‑p, pyrin (rat): V238‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  lymphoma Relevant cell lines - cell types - tissues:  monocyte, U-937 (myeloid) Cellular systems studied:  cell lines, primary cells Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes UCN-01 decrease pregnanolone decrease etiocholanolone decrease C. difficile Cytotoxin TcdA decrease