Chen C, et al. (2022) Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion. Front Pharmacol 13, 835809 35652052

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T363-p - KOR-1 (mouse) ▲

Modsite: stNRVRNtVQDPAsM SwissProt Entrez-Gene Orthologous residues KOR‑1 (human): T363‑p, KOR‑1 (mouse): T363‑p, KOR‑1 (rat): T363‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes U50488 increase MOM-SalB increase 42B increase nalfurafine no change compared to control Downstream Regulation Effect of modification (function):  receptor internalization, induced

S369-p - KOR-1 (mouse) ▲

Modsite: NtVQDPAsMRDVGGM SwissProt Entrez-Gene Orthologous residues KOR‑1 (human): Y369‑p, KOR‑1 (mouse): S369‑p, KOR‑1 (rat): S369‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes U50488 increase MOM-SalB increase 42B increase nalfurafine no change compared to control Downstream Regulation Effect of modification (function):  receptor internalization, induced