Koshino A, et al. (2021) PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer. Front Pharmacol 12, 772926 35115926

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S840-p - CDH1 (human) ▲

Modsite: FDYEGsGsEAAsLSs SwissProt Entrez-Gene Orthologous residues CDH1 (human): S840‑p, CDH1 (mouse): S842‑p, CDH1 (rat): S844‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  E.coli (bacterial), HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  bacteria, human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes PBK (human) increase Downstream Regulation Effect of modification (function):  protein stabilization Effect of modification (process):  carcinogenesis, altered, cell motility, inhibited

S844-p - CDH1 (human) ▲

Modsite: GsGsEAAsLSsLNsS SwissProt Entrez-Gene Orthologous residues CDH1 (human): S844‑p, CDH1 (mouse): S846‑p, CDH1 (rat): S848‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  E.coli (bacterial), HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  bacteria, human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes PBK (human) increase Downstream Regulation Effect of modification (function):  protein stabilization Effect of modification (process):  carcinogenesis, altered, cell motility, inhibited

S847-p - CDH1 (human) ▲

Modsite: sEAAsLSsLNsSEsD SwissProt Entrez-Gene Orthologous residues CDH1 (human): S847‑p, CDH1 (mouse): S849‑p, CDH1 (rat): S851‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  E.coli (bacterial), HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  bacteria, human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes PBK (human) increase Downstream Regulation Effect of modification (function):  protein stabilization Effect of modification (process):  carcinogenesis, altered, cell motility, inhibited