Anand R, et al. (2021) HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 34937945

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S139-p - H2AX (human) ▲

Modsite: GkkAtQAsQEy____ SwissProt Entrez-Gene Orthologous residues H2AX (human): S139‑p, H2AX (mouse): S139‑p, H2AX (rat): S139‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HEL308 (human) no change compared to control HEL308 deficiency has no effect

S4-p - RFA2 (human) ▲

Modsite: ____MWNsGFEsyGs SwissProt Entrez-Gene Orthologous residues RFA2 (human): S4‑p, RFA2 iso3 (human): G92‑p, RFA2 (mouse): S4‑p, RFA2 (rat): S4‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HEL308 (human) no change compared to control HEL308 deficiency has no effect

S8-p - RFA2 (human) ▲

Modsite: MWNsGFEsyGsssyG SwissProt Entrez-Gene Orthologous residues RFA2 (human): S8‑p, RFA2 iso3 (human): S96‑p, RFA2 (mouse): S8‑p, RFA2 (rat): S8‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HEL308 (human) no change compared to control HEL308 deficiency has no effect