Gao XQ, et al. (2021) The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression. Cell Death Differ 34588633

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S345-p - MLKL (mouse) ▲

Modsite: ELSKTQNsIsRtAKS SwissProt Entrez-Gene Orthologous residues MLKL (human): S358‑p, MLKL (mouse): S345‑p, MLKL iso2 (mouse): S345‑p, MLKL (rat): S345‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocyte-heart Cellular systems studied:  primary cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes circRNA decrease CNEACR KD increases hypoxia/reoxygenation increase circRNA hypoxia/reoxygenation inhibit treatment-induced increase CNEACR

S166-p - RIPK1 (mouse) ▲

Modsite: VAsFKTWsKLtKEKD SwissProt Entrez-Gene Orthologous residues RIPK1 (human): S166‑p, RIPK1 iso2 (human): S120‑p, RIPK1 (mouse): S166‑p, RIPK1 (rat): S166‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocyte-heart Cellular systems studied:  primary cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes circRNA no change compared to control CNEACR KD has no effect