Daly LA, et al. (2021) Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α. Sci Signal 14 34285132

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S31-p - HIF1A (human) ▲

Modsite: DAARSRRskESEVFY SwissProt Entrez-Gene Orthologous residues HIF1A (human): S31‑p, HIF1A (mouse): S31‑p, HIF1A (rat): S31‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  activity, inhibited, molecular association, regulation Effect of modification (process):  transcription, inhibited Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts

T406-p - HIF2A (human) ▲

Modsite: ELAQLAPtPGDAIIS SwissProt Entrez-Gene Orthologous residues HIF2A (human): T406‑p, HIF2A (mouse): T406‑p, HIF2A (rat): T406‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein stabilization

T528-p - HIF2A (human) ▲
Modsite: FNELDLEtLAPYIPM SwissProt Entrez-Gene Orthologous residues HIF2A (human): T528‑p, HIF2A (mouse): T527‑p, HIF2A (rat): T527‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

S581-p - HIF2A (human) ▲

Modsite: LAPVAPHsPFLLDKF SwissProt Entrez-Gene Orthologous residues HIF2A (human): S581‑p, HIF2A (mouse): G580‑p, HIF2A (rat): G580‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, altered