Malkomes P, et al. (2021) Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53. Oncogene 40, 4352-4367 34103685

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S15-p - p53 (human) ▲

Modsite: PsVEPPLsQEtFsDL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma Relevant cell lines - cell types - tissues:  HCT116 (intestinal), SW480 (intestinal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TGM2 (human) decrease TGM2 shRNA increases Downstream Regulation Effect of modification (process):  apoptosis, induced, carcinogenesis, inhibited

S46-p - p53 (human) ▲

Modsite: AMDDLMLsPDDIEQW SwissProt Entrez-Gene Orthologous residues p53 (human): S46‑p, p53 iso2 (human): S46‑p, p53 iso4 (human): S7‑p, p53 (mouse): ‑, p53 iso2 (mouse): ‑, p53 (rat): ‑, p53 (rabbit): S45‑p, p53 (green monkey): S46‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma Relevant cell lines - cell types - tissues:  HCT116 (intestinal), SW480 (intestinal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TGM2 (human) decrease TGM2 shRNA increases Downstream Regulation Effect of modification (process):  apoptosis, induced, carcinogenesis, inhibited

S392-p - p53 (human) ▲

Modsite: FktEGPDsD______ SwissProt Entrez-Gene Orthologous residues p53 (human): S392‑p, p53 iso2 (human): ‑, p53 iso4 (human): S353‑p, p53 (mouse): S389‑p, p53 iso2 (mouse): ‑, p53 (rat): S390‑p, p53 (rabbit): S390‑p, p53 (green monkey): S392‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma Relevant cell lines - cell types - tissues:  HCT116 (intestinal), SW480 (intestinal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TGM2 (human) decrease TGM2 shRNA increases Downstream Regulation Effect of modification (process):  apoptosis, induced, carcinogenesis, inhibited