Erasmus JC, et al. (2021) Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization. J Cell Biol 220 33914026

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T551-p - CTNNB1 (human) ▲
Modsite: HQDTQRRtSMGGTQQ SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T551‑p, CTNNB1 (mouse): T551‑p, CTNNB1 (rat): T551‑p, CTNNB1 (rabbit): T551‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site

S552-p - CTNNB1 (human) ▲
Modsite: QDTQRRTsMGGTQQQ SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S552‑p, CTNNB1 (mouse): S552‑p, CTNNB1 (rat): S552‑p, CTNNB1 (rabbit): S552‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site

S675-p - CTNNB1 (human) ▲

Modsite: QDYKKRLsVELTSSL SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S675‑p, CTNNB1 (mouse): S675‑p, CTNNB1 (rat): S675‑p, CTNNB1 (rabbit): S675‑p Characterization Methods used to characterize site in vivo:  immunoassay, mass spectrometry (in vitro), mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  keratinocyte Cellular systems studied:  primary cells Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK1 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CDH1 (human) Induces in vitro

T248-p - GDI2 (human) ▲
Modsite: LSAIYGGtYMLNKPI SwissProt Entrez-Gene Orthologous residues GDI2 (human): T248‑p, GDI2 iso2 (human): T203‑p, GDI2 (mouse): T248‑p, GDI2 (rat): T248‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK1 (human)

S382-p - GDI2 (human) ▲

Modsite: PIEQKFVsISDLLVP SwissProt Entrez-Gene Orthologous residues GDI2 (human): S382‑p, GDI2 iso2 (human): S337‑p, GDI2 (mouse): S382‑p, GDI2 (rat): S382‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  keratinocyte Cellular systems studied:  primary cells Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK1 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays RAB5A (human) Induces co-immunoprecipitation RAB11A (human) Induces intracellular localization co-immunoprecipitation