Curated Information
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Home > Curated Information Page > PubMed Id: 33781876
Wang C, et al. (2021) Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats. J Ethnopharmacol 274, 114072 33781876
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S473-p - Akt1 (rat)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
olanzapine increase
Longdan Xiegan Tang olanzapine inhibit treatment-induced increase

S302-p - IRS1 (rat)
Modsite: TRRSRTEsITATsPA SwissProt Entrez-Gene
Orthologous residues
IRS1 (human): S307‑p, IRS1 (mouse): S302‑p, IRS1 (rat): S302‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
olanzapine increase
Longdan Xiegan Tang olanzapine inhibit treatment-induced increase

S724-p - IRS2 (rat)
Modsite: GGGYKASsPAESsPE SwissProt Entrez-Gene
Orthologous residues
IRS2 (human): S731‑p, IRS2 (mouse): S723‑p, IRS2 (rat): S724‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
olanzapine increase
Longdan Xiegan Tang olanzapine inhibit treatment-induced increase

Y607-p - PIK3R1 (rat)
Modsite: NENTEDQysLVDDDE SwissProt Entrez-Gene
Orthologous residues
PIK3R1 (human): Y607‑p, PIK3R1 iso2 (human): Y337‑p, PIK3R1 iso4 (human): Y615‑p, PIK3R1 (mouse): Y607‑p, PIK3R1 (rat): Y607‑p, PIK3R1 (cow): Y607‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
olanzapine increase
Longdan Xiegan Tang olanzapine inhibit treatment-induced increase