Mattè A, et al. (2021) Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells. Antioxidants (Basel) 10 33535382

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

Y115-p - PRDX2 (human) ▲

Modsite: TRrLsEDyGVLktDE SwissProt Entrez-Gene Orthologous residues PRDX2 (human): Y115‑p, PRDX2 iso2 (human): ‑, PRDX2 (mouse): Y115‑p, PRDX2 (rat): Y115‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Relevant cell lines - cell types - tissues:  erythrocyte-blood Cellular systems studied:  primary cultured cells Species studied:  mouse

Y193-p - PRDX2 (human) ▲

Modsite: NVDDskEyFskHN__ SwissProt Entrez-Gene Orthologous residues PRDX2 (human): Y193‑p, PRDX2 iso2 (human): ‑, PRDX2 (mouse): Y193‑p, PRDX2 (rat): Y193‑p Characterization Methods used to characterize site in vivo:  2D analysis, mass spectrometry, mass spectrometry (in vitro), phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  erythrocyte-blood Cellular systems studied:  primary cultured cells Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE Syk (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Syk (human) phospho-antibody, co-immunoprecipitation, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes PP1, PP2 decrease diamide increase PP1, PP2 inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  enzymatic activity, induced, intracellular localization, protein conformation Associated Diseases Diseases Alterations Comments sickle-cell anaemia increased