Hryniewicz-Jankowska A, et al. (2021) The Effect of Neddylation Inhibition on Inflammation-Induced MMP9 Gene Expression in Esophageal Squamous Cell Carcinoma. Int J Mol Sci 22 33572115

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S32-p - IkB-alpha (human) ▲

Modsite: LLDDRHDsGLDsMkD SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  esophageal cancer, esophageal carcinoma Relevant cell lines - cell types - tissues:  Kyse150 (esophageal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MLN4924 increase TNF increase TNF, MLN4924 increase Downstream Regulation Effect of modification (function):  intracellular localization, protein degradation, protein stabilization Comments:  Regulates degradation or stabilization by itself depending on the treatment

S46-p - p53 (human) ▲

Modsite: AMDDLMLsPDDIEQW SwissProt Entrez-Gene Orthologous residues p53 (human): S46‑p, p53 iso2 (human): S46‑p, p53 iso4 (human): S7‑p, p53 (mouse): ‑, p53 iso2 (mouse): ‑, p53 (rat): ‑, p53 (rabbit): S45‑p, p53 (green monkey): S46‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Disease tissue studied:  esophageal cancer, esophageal carcinoma Relevant cell lines - cell types - tissues:  Kyse150 (esophageal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MLN4924 no change compared to control TNF no change compared to control TNF, MLN4924 no change compared to control

Y701-p - STAT1 (human) ▲

Modsite: DGPkGtGyIktELIs SwissProt Entrez-Gene Orthologous residues STAT1 (human): Y701‑p, STAT1 iso2 (human): Y701‑p, STAT1 (mouse): Y701‑p, STAT1 (rat): Y701‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Disease tissue studied:  esophageal cancer, esophageal carcinoma Relevant cell lines - cell types - tissues:  Kyse150 (esophageal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MLN4924 decrease TNF no change compared to control TNF, MLN4924 decrease

Y690-p - STAT2 (human) ▲

Modsite: NLQERRKyLKHRLIV SwissProt Entrez-Gene Orthologous residues STAT2 (human): Y690‑p, STAT2 (mouse): Y689‑p, STAT2 iso3 (mouse): Y688‑p, STAT2 (rat): Y690‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Disease tissue studied:  esophageal cancer, esophageal carcinoma Relevant cell lines - cell types - tissues:  Kyse150 (esophageal) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MLN4924 increase TNF increase TNF, MLN4924 increase