Curated Information
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Home > Curated Information Page > PubMed Id: 33410863
Lorenzini M, et al. (2021) Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. J Gen Physiol 153 33410863
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S457-p - SCN5A (human)
Modsite: IRGVDtVsRssLEMs SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S457‑p, SCN5A (mouse): S457‑p, SCN5A (rat): S458‑p

S459-p - SCN5A (human)
Modsite: GVDtVsRssLEMsPL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S459‑p, SCN5A (mouse): S459‑p, SCN5A (rat): S460‑p

S460-p - SCN5A (human)
Modsite: VDtVsRssLEMsPLA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S460‑p, SCN5A (mouse): S460‑p, SCN5A (rat): S461‑p

S483-p - SCN5A (human)
Modsite: sKRRKRMssGtEECG SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S483‑p, SCN5A (mouse): S483‑p, SCN5A (rat): S484‑p
Downstream Regulation
Effect of modification (function):  protein conformation

S484-p - SCN5A (human)
Modsite: KRRKRMssGtEECGE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S484‑p, SCN5A (mouse): S484‑p, SCN5A (rat): S485‑p
Downstream Regulation
Effect of modification (function):  protein conformation

T486-p - SCN5A (human)
Modsite: RKRMssGtEECGEDR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T486‑p, SCN5A (mouse): T486‑p, SCN5A (rat): T487‑p
Downstream Regulation
Effect of modification (function):  protein conformation

S497-p - SCN5A (human)
Modsite: GEDRLPKsDsEDGPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S497‑p, SCN5A (mouse): S497‑p, SCN5A (rat): S498‑p

S499-p - SCN5A (human)
Modsite: DRLPKsDsEDGPRAM SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S499‑p, SCN5A (mouse): S499‑p, SCN5A (rat): S500‑p

S664-p - SCN5A (human)
Modsite: GARQRALsAVsVLts SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S664‑p, SCN5A (mouse): S664‑p, SCN5A (rat): S665‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TAC increase
Downstream Regulation
Effect of modification (function):  activity, induced, protein conformation
Comments:  regulates the voltage-dependence of current activation

S667-p - SCN5A (human)
Modsite: QRALsAVsVLtsALE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S667‑p, SCN5A (mouse): S667‑p, SCN5A (rat): S668‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TAC increase
Downstream Regulation
Effect of modification (function):  activity, induced, protein conformation
Comments:  regulates the voltage-dependence of current activation

T670-p - SCN5A (human)
Modsite: LsAVsVLtsALEELE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T670‑p, SCN5A (mouse): T670‑p, SCN5A (rat): T671‑p
Downstream Regulation
Effect of modification (function):  protein conformation

S671-p - SCN5A (human)
Modsite: sAVsVLtsALEELEE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S671‑p, SCN5A (mouse): S671‑p, SCN5A (rat): S672‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TAC increase
Downstream Regulation
Effect of modification (function):  activity, inhibited, intracellular localization, protein conformation
Comments:  the SCN5A S671E channel shows a decrease in peak Na+ current density

S12-p - SCN5A (mouse)
Modsite: LLPRGTSsFRRFTRE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S12‑p, SCN5A (mouse): S12‑p, SCN5A (rat): S12‑p

S36-p - SCN5A (mouse)
Modsite: AEKQARGsAtsQEsR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S36‑p, SCN5A (mouse): S36‑p, SCN5A (rat): S37‑p

S39-p - SCN5A (mouse)
Modsite: QARGsAtsQEsREGL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): L39‑p, SCN5A (mouse): S39‑p, SCN5A (rat): S40‑p

S42-p - SCN5A (mouse)
Modsite: GsAtsQEsREGLPEE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S42‑p, SCN5A (mouse): S42‑p, SCN5A (rat): S43‑p

S457-p - SCN5A (mouse)
Modsite: IRGVDTVsRssLEMS SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S457‑p, SCN5A (mouse): S457‑p, SCN5A (rat): S458‑p

S459-p - SCN5A (mouse)
Modsite: GVDTVsRssLEMSPL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S459‑p, SCN5A (mouse): S459‑p, SCN5A (rat): S460‑p

S460-p - SCN5A (mouse)
Modsite: VDTVsRssLEMSPLA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S460‑p, SCN5A (mouse): S460‑p, SCN5A (rat): S461‑p

S483-p - SCN5A (mouse)
Modsite: SKRRKRLssGtEDGG SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S483‑p, SCN5A (mouse): S483‑p, SCN5A (rat): S484‑p

S484-p - SCN5A (mouse)
Modsite: KRRKRLssGtEDGGD SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S484‑p, SCN5A (mouse): S484‑p, SCN5A (rat): S485‑p

T486-p - SCN5A (mouse)
Modsite: RKRLssGtEDGGDDR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T486‑p, SCN5A (mouse): T486‑p, SCN5A (rat): T487‑p

S497-p - SCN5A (mouse)
Modsite: GDDRLPKsDsEDGPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S497‑p, SCN5A (mouse): S497‑p, SCN5A (rat): S498‑p

S499-p - SCN5A (mouse)
Modsite: DRLPKsDsEDGPRAL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S499‑p, SCN5A (mouse): S499‑p, SCN5A (rat): S500‑p

S510-p - SCN5A (mouse)
Modsite: PRALNQLsLTHGLsR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S510‑p, SCN5A (mouse): S510‑p, SCN5A (rat): S511‑p

S516-p - SCN5A (mouse)
Modsite: LsLTHGLsRTSMRPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S516‑p, SCN5A (mouse): S516‑p, SCN5A (rat): S517‑p

S525-p - SCN5A (mouse)
Modsite: TSMRPRssrGsIFTF SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S525‑p, SCN5A (mouse): S525‑p, SCN5A (rat): S526‑p

S539-p - SCN5A (mouse)
Modsite: FRRRDQGsEADFADD SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S539‑p, SCN5A (mouse): S539‑p, SCN5A (rat): S540‑p

S549-p - SCN5A (mouse)
Modsite: DFADDENsTAGESES SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S549‑p, SCN5A (mouse): S549‑p, SCN5A (rat): S550‑p

S560-p - SCN5A (mouse)
Modsite: ESESHRTsLLVPWPL SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S560‑p, SCN5A (mouse): S560‑p, SCN5A (rat): S561‑p

S571-p - SCN5A (mouse)
Modsite: PWPLRRPsTQGQPGF SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S571‑p, SCN5A (mouse): S571‑p, SCN5A (rat): S572‑p

S581-p - SCN5A (mouse)
Modsite: GQPGFGTsAPGHVLN SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S581‑p, SCN5A (mouse): S581‑p, SCN5A (rat): S582‑p

S593-p - SCN5A (mouse)
Modsite: VLNGKRNsTVDCNGV SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S593‑p, SCN5A (mouse): S593‑p, SCN5A (rat): S594‑p

S664-p - SCN5A (mouse)
Modsite: GARQRALsAVsVLts SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S664‑p, SCN5A (mouse): S664‑p, SCN5A (rat): S665‑p

S667-p - SCN5A (mouse)
Modsite: QRALsAVsVLtsALE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S667‑p, SCN5A (mouse): S667‑p, SCN5A (rat): S668‑p

T670-p - SCN5A (mouse)
Modsite: LsAVsVLtsALEELE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T670‑p, SCN5A (mouse): T670‑p, SCN5A (rat): T671‑p

S671-p - SCN5A (mouse)
Modsite: sAVsVLtsALEELEE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S671‑p, SCN5A (mouse): S671‑p, SCN5A (rat): S672‑p

T999-p - SCN5A (mouse)
Modsite: KKPAALAtHsQLPsC SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): A997‑p, SCN5A (mouse): T999‑p, SCN5A (rat): T1000‑p

S1001-p - SCN5A (mouse)
Modsite: PAALAtHsQLPsCIA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): G999‑p, SCN5A (mouse): S1001‑p, SCN5A (rat): S1002‑p

S1005-p - SCN5A (mouse)
Modsite: AtHsQLPsCIAAPRs SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1003‑p, SCN5A (mouse): S1005‑p, SCN5A (rat): S1006‑p

S1012-p - SCN5A (mouse)
Modsite: sCIAAPRsPPPPEVE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1010‑p, SCN5A (mouse): S1012‑p, SCN5A (rat): S1013‑p

S1056-p - SCN5A (mouse)
Modsite: VPIAVAEsDtDDQEE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1054‑p, SCN5A (mouse): S1056‑p, SCN5A (rat): S1057‑p

T1058-p - SCN5A (mouse)
Modsite: IAVAEsDtDDQEEDE SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T1056‑p, SCN5A (mouse): T1058‑p, SCN5A (rat): T1059‑p

T1104-p - SCN5A (mouse)
Modsite: WSQVSETtSsEAEAS SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): A1102‑p, SCN5A (mouse): T1104‑p, SCN5A (rat): T1104‑p

S1106-p - SCN5A (mouse)
Modsite: QVSETtSsEAEASTS SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1104‑p, SCN5A (mouse): S1106‑p, SCN5A (rat): S1106‑p

S1137-p - SCN5A (mouse)
Modsite: CGETPEDsYSEGSTA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1135‑p, SCN5A (mouse): S1137‑p, SCN5A (rat): S1137‑p

T1808-p - SCN5A (mouse)
Modsite: EKFDPEAtQFIEYLA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): T1806‑p, SCN5A (mouse): T1808‑p, SCN5A (rat): T1808‑p

S1936-p - SCN5A (mouse)
Modsite: LFRQQAGssGLSDED SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1934‑p, SCN5A (mouse): S1936‑p, SCN5A (rat): G1936‑p

S1963-p - SCN5A (mouse)
Modsite: NENFSRRsGPLSsSs SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): L1960‑p, SCN5A (mouse): S1963‑p, SCN5A (rat): S1963‑p

S1968-p - SCN5A (mouse)
Modsite: RRsGPLSsSsIssTS SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1965‑p, SCN5A (mouse): S1968‑p, SCN5A (rat): S1968‑p

S1970-p - SCN5A (mouse)
Modsite: sGPLSsSsIssTSFP SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1967‑p, SCN5A (mouse): S1970‑p, SCN5A (rat): S1970‑p

S1972-p - SCN5A (mouse)
Modsite: PLSsSsIssTSFPPS SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1969‑p, SCN5A (mouse): S1972‑p, SCN5A (rat): S1972‑p

S1973-p - SCN5A (mouse)
Modsite: LSsSsIssTSFPPSY SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1970‑p, SCN5A (mouse): S1973‑p, SCN5A (rat): S1973‑p

S1988-p - SCN5A (mouse)
Modsite: DSVTRATsDNLPVRA SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S1985‑p, SCN5A (mouse): S1988‑p, SCN5A (rat): S1988‑p

S2010-p - SCN5A (mouse)
Modsite: DLADFPPsPDRDRES SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S2007‑p, SCN5A (mouse): S2010‑p, SCN5A (rat): S2010‑p