Curated Information
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Home > Curated Information Page > PubMed Id: 21493671
Kao YJ, Ghosh M, Schonbrunn A (2011) Ligand-Dependent Mechanisms of sst2A Receptor Trafficking: Role of Site-Specific Phosphorylation and Receptor Activation in the Actions of Biased Somatostatin Agonists. Mol Endocrinol 25, 1040-54 21493671
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S341-p - SSTR2 (rat)
Modsite: GAEDGERsDsKQDKs SwissProt
Orthologous residues
SSTR2 (human): S341‑p, SSTR2 (mouse): S341‑p, SSTR2 (rat): S341‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CHO (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
pasireotide increase slight increase
KE108 increase

S343-p - SSTR2 (rat)
Modsite: EDGERsDsKQDKsRL SwissProt
Orthologous residues
SSTR2 (human): S343‑p, SSTR2 (mouse): S343‑p, SSTR2 (rat): S343‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CHO (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
pasireotide increase slight increase
KE108 increase

T353-p - SSTR2 (rat)
Modsite: DKsRLNEttEtQRtL SwissProt
Orthologous residues
SSTR2 (human): T353‑p, SSTR2 (mouse): T353‑p, SSTR2 (rat): T353‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CHO (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
pasireotide increase slight increase
KE108 increase slight increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered

T354-p - SSTR2 (rat)
Modsite: KsRLNEttEtQRtLL SwissProt
Orthologous residues
SSTR2 (human): T354‑p, SSTR2 (mouse): T354‑p, SSTR2 (rat): T354‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CHO (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
pasireotide increase slight increase
KE108 increase slight increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered