Curated Information
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Home > Curated Information Page > PubMed Id: 33275877
Cho EA, et al. (2020) Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM. Structure 33275877
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y267-p - RIAM (mouse)
Modsite: FLEKEERyAVFKNPQ SwissProt Entrez-Gene
Orthologous residues
RIAM (human): Y264‑p, RIAM (mouse): Y267‑p, RIAM (rat): Y266‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  hamster, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (mouse)
KINASE Lck (mouse)
Downstream Regulation
Effect of modification (function):  activity, induced, intracellular localization
Effect of modification (process):  cell adhesion, induced, signaling pathway regulation
Comments:  induces integrin activation/ integrin signaling pathway

Y427-p - RIAM (mouse)
Modsite: AKYGKTLyDNYQRAV SwissProt Entrez-Gene
Orthologous residues
RIAM (human): Y424‑p, RIAM (mouse): Y427‑p, RIAM (rat): Y425‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  hamster, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Lck (mouse)
KINASE Fyn (mouse)
Downstream Regulation
Effect of modification (function):  activity, induced, intracellular localization
Effect of modification (process):  cell adhesion, induced, signaling pathway regulation
Comments:  induces integrin activation/ integrin signaling pathway