Park H, et al. (2020) Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy. J Biol Chem 33293370

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T79-p - EWS (human) ▲

Modsite: QPPTGYTtPTAPQAY SwissProt Entrez-Gene Orthologous residues EWS (human): T79‑p, EWS iso2 (human): T79‑p, EWS iso3 (human): T79‑p, EWS iso4 (human): T79‑p, EWS iso5 (human): T85‑p, EWS (mouse): T79‑p, EWS (rat): T79‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, western blotting Disease tissue studied:  Ewing's sarcoma, colorectal cancer, colorectal carcinoma Relevant cell lines - cell types - tissues:  A673 (muscle cell), DLD1 (intestinal), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  cell cycle regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays AurB (human) Induces intracellular localization cell cycle regulation microscopy-colocalization Comments:  as EWS/FLI1 fusion; induces aneuploidy in EWS/FLI1 cells