Lim Y, et al. (2020) Phosphorylation by Aurora B kinase regulates caspase-2 activity and function. Cell Death Differ 32811973

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S24-p - CASP2 (mouse) ▲

Modsite: LMAADrRsRILAVCG SwissProt Entrez-Gene Orthologous residues CASP2 (human): R24‑p, CASP2 (mouse): S24‑p, CASP2 (rat): S24‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S80-p - CASP2 (mouse) ▲

Modsite: LIQAKGGsFSQNVEL SwissProt Entrez-Gene Orthologous residues CASP2 (human): S80‑p, CASP2 (mouse): S80‑p, CASP2 (rat): S80‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S157-p - CASP2 (mouse) ▲
Modsite: PHKQLRLstDAtEHs SwissProt Entrez-Gene Orthologous residues CASP2 (human): S157‑p, CASP2 (mouse): S157‑p, CASP2 (rat): S157‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

T158-p - CASP2 (mouse) ▲

Modsite: HKQLRLstDAtEHsL SwissProt Entrez-Gene Orthologous residues CASP2 (human): T158‑p, CASP2 (mouse): T158‑p, CASP2 (rat): T158‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

T161-p - CASP2 (mouse) ▲

Modsite: LRLstDAtEHsLDNG SwissProt Entrez-Gene Orthologous residues CASP2 (human): V161‑p, CASP2 (mouse): T161‑p, CASP2 (rat): M161‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S164-p - CASP2 (mouse) ▲
Modsite: stDAtEHsLDNGDGP SwissProt Entrez-Gene Orthologous residues CASP2 (human): S164‑p, CASP2 (mouse): S164‑p, CASP2 (rat): S164‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

T180-p - CASP2 (mouse) ▲

Modsite: CLLVKPCtPEFYQAH SwissProt Entrez-Gene Orthologous residues CASP2 (human): T180‑p, CASP2 (mouse): T180‑p, CASP2 (rat): T180‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S220-p - CASP2 (mouse) ▲

Modsite: EKDLEFRsGGDVDHT SwissProt Entrez-Gene Orthologous residues CASP2 (human): S220‑p, CASP2 (mouse): S220‑p, CASP2 (rat): S220‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S340-p - CASP2 (mouse) ▲
Modsite: DGKNHTQsPGCEEsD SwissProt Entrez-Gene Orthologous residues CASP2 (human): S340‑p, CASP2 (mouse): S340‑p, CASP2 (rat): S340‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S346-p - CASP2 (mouse) ▲

Modsite: QsPGCEEsDAGKEEL SwissProt Entrez-Gene Orthologous residues CASP2 (human): S346‑p, CASP2 (mouse): S346‑p, CASP2 (rat): S346‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human

S384-p - CASP2 (mouse) ▲

Modsite: MRNTKRGsWYIEALT SwissProt Entrez-Gene Orthologous residues CASP2 (human): S384‑p, CASP2 (mouse): S384‑p, CASP2 (rat): S384‑p Characterization Methods used to characterize site in vivo:  immunoassay, mass spectrometry, mutation of modification site Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  A549 (pulmonary), E.coli (bacterial), U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  bacteria, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE AurB (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE AurB (human) modification site within consensus motif, co-immunoprecipitation, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ZM447439 decrease Downstream Regulation Effect of modification (function):  enzymatic activity, inhibited Effect of modification (process):  apoptosis, inhibited, cell cycle regulation