Curated Information
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Home > Curated Information Page > PubMed Id: 28555617
Yoshimaru T, et al. (2017) A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells. Nat Commun 8, 15427 28555617
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S39-p - BAP37 (human)
Modsite: VAyGVREsVFTVEGG SwissProt Entrez-Gene
Orthologous residues
BAP37 (human): S39‑p, BAP37 iso2 (human): S39‑p, BAP37 (mouse): S39‑p, BAP37 (rat): S39‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PPP1CA (human)
KINASE PKCA (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) phospho-antibody, siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
17-beta-estradiol no change compared to control
peptide inhibitor 17-beta-estradiol increase ERAP, dominant-negative peptide inhibitors
Associated Diseases
Diseases Alterations Comments
breast cancer decreased ER-alpha positive breast cancers-poor prognosis