Curated Information
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Home > Curated Information Page > PubMed Id: 32159413
Hapil FZ, et al. (2020) Negative Regulation of TNFR1 Signaling Via PKA-Mediated Phosphorylation of TNFR1. J Interferon Cytokine Res 32159413
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T411-p - TNF-R1 (human)
Modsite: LAtWRRRtPRREAtL SwissProt Entrez-Gene
Orthologous residues
TNF‑R1 (human): T411‑p, TNF‑R1 (mouse): T411‑p, TNF‑R1 (rat): T418‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) phospho-motif antibody, co-immunoprecipitation, modification site within consensus motif, pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation, phosphorylation
Effect of modification (process):  apoptosis, induced, signaling pathway regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRB2 (human) Disrupts co-immunoprecipitation
Comments:  non-canonical TNF-alpha signaling, necrosis induced; decrease ERK, Akt and STAT3 phosphorylation

T417-p - TNF-R1 (human)
Modsite: RtPRREAtLELLGRV SwissProt Entrez-Gene
Orthologous residues
TNF‑R1 (human): T417‑p, TNF‑R1 (mouse): T417‑p, TNF‑R1 (rat): T424‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) phospho-motif antibody, co-immunoprecipitation, modification site within consensus motif, pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation, phosphorylation
Effect of modification (process):  apoptosis, induced, signaling pathway regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRB2 (human) Disrupts co-immunoprecipitation
Comments:  non-canonical TNF-alpha signaling, necrosis induced; decrease ERK, Akt and STAT3 phosphorylation