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Home > Curated Information Page > PubMed Id: 32117957
Tan W, van Twest S, Murphy VJ, Deans AJ (2020) ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2. Front Cell Dev Biol 8, 2 32117957
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S556-p - FANCI (human)
Modsite: VLGSLSSsQCsQSLS SwissProt Entrez-Gene
Orthologous residues
FANCI (human): S556‑p, FANCI iso1 (human): S556‑p, FANCI (mouse): S555‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Induces EMSA
Comments:  prevents deubiquitination of FANCD2

S559-p - FANCI (human)
Modsite: SLSSsQCsQSLSVsQ SwissProt Entrez-Gene
Orthologous residues
FANCI (human): S559‑p, FANCI iso1 (human): S559‑p, FANCI (mouse): T558‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Induces EMSA
Comments:  prevents deubiquitination of FANCD2

S565-p - FANCI (human)
Modsite: CsQSLSVsQVHVDVH SwissProt Entrez-Gene
Orthologous residues
FANCI (human): S565‑p, FANCI iso1 (human): S565‑p, FANCI (mouse): T564‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Induces EMSA
Comments:  prevents deubiquitination of FANCD2