Curated Information
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Home > Curated Information Page > PubMed Id: 32071234
Yong AJH, et al. (2020) Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. Proc Natl Acad Sci U S A 32071234
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y876-p - GluR2 (human)
Modsite: YKEGYNVyGIEsVKI SwissProt Entrez-Gene
Orthologous residues
GluR2 (human): Y876‑p, GluR2 iso2 (human): Y876‑p, GluR2 (mouse): Y876‑p, GluR2 iso3 (mouse): , GluR2 (rat): Y876‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', 'neuron, cortical'-brain, 293 (epithelial)
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse

Y876-p - GluR2 (mouse)
Modsite: YkEGYNVyGIEsVKI SwissProt Entrez-Gene
Orthologous residues
GluR2 (human): Y876‑p, GluR2 iso2 (human): Y876‑p, GluR2 (mouse): Y876‑p, GluR2 iso3 (mouse): , GluR2 (rat): Y876‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', 'neuron, cortical'-brain, 293 (epithelial)
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
PP2 decrease

S880-p - GluR2 (mouse)
Modsite: YNVyGIEsVKI____ SwissProt Entrez-Gene
Orthologous residues
GluR2 (human): S880‑p, GluR2 iso2 (human): S880‑p, GluR2 (mouse): S880‑p, GluR2 iso3 (mouse): , GluR2 (rat): S880‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', 'neuron, cortical'-brain, 293 (epithelial)
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse

Y881-p - GluR3 (mouse)
Modsite: YREGYNVyGTEsVKI SwissProt Entrez-Gene
Orthologous residues
GluR3 (human): Y887‑p, GluR3 iso2 (human): Y887‑p, GluR3 (mouse): Y881‑p, GluR3 (rat): Y881‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', 'neuron, cortical'-brain, 293 (epithelial)
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
PP2 decrease
vanadate GluR2 (mouse) no effect upon treatment-induced increase Y876F mutant
PP2 GluR2 (mouse) no effect upon treatment-induced decrease Y876F mutant

S885-p - GluR3 (mouse)
Modsite: YNVyGTEsVKI____ SwissProt Entrez-Gene
Orthologous residues
GluR3 (human): S891‑p, GluR3 iso2 (human): S891‑p, GluR3 (mouse): S885‑p, GluR3 (rat): S885‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', 'neuron, cortical'-brain, 293 (epithelial)
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse