Nowacka A, et al. (2020) PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD. Sci Rep 10, 2054 32029829

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S73-p - PSD-95 (rat) ▲

Modsite: ITLERGNsGLGFSIA SwissProt Entrez-Gene Orthologous residues PSD‑95 (human): S73‑p, PSD‑95 iso2 (human): S116‑p, PSD‑95 (mouse): S73‑p, PSD‑95 (rat): S73‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site Relevant cell lines - cell types - tissues:  'brain, hippocampus, CA1 region' Cellular systems studied:  tissue Species studied:  rat Comments:  hippocampal slices Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CAMK2A (rat) pharmacological inhibitor of upstream enzyme, siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes KN-62 decrease siRNA decrease siRNA for CAMK2A decreases phosphorylation Downstream Regulation Comments:  PSD-95 downregulation