Song WJ, et al. (2011) Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab 13, 308-19 21356520

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S50-p - SNAPIN (human) ▲

Modsite: HVHAVREsQVELREQ SwissProt Entrez-Gene Orthologous residues SNAPIN (human): S50‑p, SNAPIN (mouse): S50‑p, SNAPIN (rat): S50‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  pancreatic cancer, pancreatic carcinoma Relevant cell lines - cell types - tissues:  INS-1 (pancreatic) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes exenatide increase mPKI exenatide inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SNAP-25 (human) Induces co-immunoprecipitation VAMP2 (human) Induces co-immunoprecipitation RAPGEF4 (human) Induces co-immunoprecipitation TMEM27 (human) Induces co-immunoprecipitation Comments:  potentiates glucose-stimulated insulin secretion (GSIS)

S50-gl - SNAPIN (human) ▲

Modsite: HVHAVREsQVELREQ SwissProt Entrez-Gene Orthologous residues SNAPIN (human): S50‑gl, SNAPIN (mouse): S50‑gl, SNAPIN (rat): S50‑gl Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  pancreatic cancer, pancreatic carcinoma Relevant cell lines - cell types - tissues:  INS-1 (pancreatic) Cellular systems studied:  cell lines Species studied:  rat